Angiogenesis is essential to tumour development

A hallmark of cancer throughout tumour development

While there are many distinct types of cancer (and considerable heterogeneity within each tumour type), there exists a remarkable similarity in the pathological traits that collectively drive tumour growth. Across most, if not all, malignancies, sustained angiogenesis is considered to be one of these central hallmarks of cancer¹

In their seminal review paper, 'The hallmarks of cancer', Hanahan and Weinberg proposed six acquired capabilities of cancer cells and gave examples of possible enabling mechanisms.¹

Acquired capabilities of cancer

Angiogenesis is one of the key cellular transformations that lead to malignant growth

REFERENCES
1. Hanahan D, Weinberg RA. Cell 2000;100:57–70.